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Investigating A Potential Medication for PTSD That May Help Sleep


Find out more and take the questionnaire

*Your records relating to this study and any other information received will be kept strictly confidential.

This research study is called REST. It explores the effectiveness of an FDA-approved medication called doxazosin on sleep and PTSD symptoms, including nightmares. 

Existing research shows that this medication may effectively treat sleep problems, nightmares, and other PTSD symptoms. However, there is still a need for better studies to demonstrate that this medication is effective for PTSD treatment.

Why Participate?

  • Participants may experience a reduction in the severity and frequency of their nightmares, an improvement in their sleep, and a potential reduction in other PTSD symptoms.
  • Participants may help researchers learn more about the effects of this potential treatment on sleep.
  • Participants may contribute valuable information that may benefit others with PTSD and sleep problems related to PTSD in the future.
  • Participants will be compensated up to $530 for participating in this study, depending on which phase of the study they complete.
  • Participants will be helping to advance medical and mental health research.

Who Can Participate?

  • Adults aged 18 to 60 years old who have symptoms of PTSD and are experiencing nightmares related to a traumatic event.
  • This study is inviting those who are U.S. Military Veterans to join this study.
  • Must not have a psychiatric disorder with symptoms of psychosis or a manic episode within the last 5 years.
  • This research study will take about 9.5 weeks to complete. There may be 1 study visit at the research site or partnered laboratory site near the participant depending on their location. However, participants will be given the option to participate remotely in study visits. If they choose this option, 1 or more home visits by study staff may be required in order to set up video conferencing equipment. All video conferencing equipment is expected to be returned at the end of your study participation. Permission from the study doctor is needed for remote participation.
  • Some study requirements include but are not limited to:
  • Completing questionnaires and surveys.
  • Completing daily sleep diary entries through an app that will be downloaded into the participant’s electronic device (i.e., smartphone).
  • Wearing a monitoring device, called an actigraph, which will measure wrist movement during wake and sleep. Participants may be asked to wear this device on their wrist, like a watch, at all times for 7 days and 7 nights, except during bathing, at three timepoints during the study.
  • This study may involve the study staff reviewing medical records, having at-home sleep apnea screening, Laboratory tests, and EKG readings (if needed).

Please note that any study materials that would be mailed to the participants and would be needed back, the study team will include a prepaid return mailer. Participants may have to drop off packages to send back to the study team at their local UPS, FedEx, USPS, etc.

Meet the Lead Researcher

Anne Richards, M.D., M.P.H.

Anne Richards, M.D., M.P.H., is a PTSD, sleep, and sex differences researcher in the Stress and Health Research Program at the San Francisco VA Medical Center. Dr. Richards also serves as an Associate Clinical Professor at the University of California, San Francisco, and is a Staff Psychiatrist at the San Francisco VA Medical Center. Dr. Richards completed her undergraduate education at Harvard University and subsequently received her M.D. and M.P.H. from Columbia University. Dr. Richards has expertise in the treatment of PTSD and sleep disorders gained through years of experience treating male and female veterans with PTSD with medication and psychotherapy.

Study Details

Research Center: NCIRE-The Veterans Health Research Institute and the San Francisco VA Medical Center

Location: This research study can be done from your home within the state of California

Lead Researcher: Anne Richards, M.D., M.P.H.

IRB Committee: This study has also been reviewed and approved by the San Francisco VA Medical Center.

About the Research Center:

NCIRE - The Veterans Health Research Institute

Since 1988, NCIRE-supported scientists and clinicians have been at the front lines of Veterans health research, developing novel treatments for the wide range of conditions that affect Veterans of all ages. They support over 200 researchers who have joint faculty appointments at University of California San Francisco (UCSF) and San Francisco VA (SFVA) Medical Center. Their broad portfolio of projects receives generous support from the National Institutes of Health, the Department of Defense, and individual donors, making them the leading nonprofit research institute devoted to Veterans health in the U.S. Their goals are to continue to advance science, promote education, and foster innovation through leadership in the field of Veterans health research.

Please note:

Due to the current situation with the COVID-19 pandemic, the researchers would like to assure the participants that ensuring the safety of the participants as well as the study staff is of utmost importance.

Your Rights

  • If you decide to participate in the study and later feel that you no longer wish to be part of it, you may withdraw at any time. 
  • Your records relating to this study and any other information received will be kept strictly confidential, except as required by the law.
  • Qualified health professionals will monitor your health as it relates to the study.

Next Steps

  1. Click the link below to enter your contact details and answer some eligibility questions.
  2. The research center will then contact you by phone to discuss the trial and answer your questions.

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